Thomas exited in the second quarter against the Browns with a shoulder issue. He had three receptions prior to his exit and is questionable to return. Rookie Josh Cameron will see more opportunities while Thomas is out.
Flowers has been dealing with a hamstring injury, but that didn’t appear to slow him early on. In one half of play, Flowers has caught five passes for 150 yards and one touchdown, and had receptions of 49 and 54 yards. We’ll see if Flowers can return in the second half, but if not, Lamar Jackson will have Rashod Bateman and Ja’Kobi Lane as his top two receivers the rest of the way.
The maligned first-round rookie had a rugged, 30-yard catch-and-run to the Titans’ four-yard line on the Jets’ opening series, but got his right ankle rolled up on in the process. He required the assistance of a cart, but the Jets claimed he might still return. He was then ruled out at halftime. It’s a brutal blow for a first-rounder who supposedly had a rough summer. Despite the delayed ruleout, Cooper should definitely be considered on the wrong side of questionable for Week 2. If he is occupying one of your final bench spots, he will be a shaky hold during this week’s all-important waivers run.
The offseason trade acquisition went down very early in the proceedings, though the Jets claimed he was “questionable.” He was seen trying to warm up and return. He was then downgraded to “doubtful” after halftime, and would appear to be done for the afternoon. Injuries have been an ongoing issue for the 29-year-old, though they are typically not of the season-ending variety. The fact that Fitzpatrick tried to return today suggests he could be out there for Week 2.
Sampson went to the medical tent during the first quarter of the Browns’ Week 1 game against the Jaguars. He then headed to the locker room to be further evaluated for a knee injury and is questionable to return. Sampson is the Browns’ third-down/passing-down back; Quinshon Judkins will see more of those snaps while Sampson is out.
Sampson returned a kickoff and played on a third down play against the Jaguars before exiting in the first quarter. He left for the locker room with a knee injury and was promptly ruled out. Third-string running back Raheim Sanders will get more run with Sampson out.
Schefter added Brown will miss four to six weeks with the high ankle sprain he sustained on Wednesday night against the Seahawks. It could be much longer than that before Brown is back to full health and operating as the Patriots’ alpha WR1. For now, Mack Hollins will slide into three-receiver sets and Romeo Doubs — who didn’t catch any of his three targets against Seattle — will likely function as Drake Maye’s top option. Demario Douglas could be an interesting add in deeper formats after leading the team with seven targets in Week 1.
Bowers underwent a meniscus trim on Tuesday after getting banged up in training camp. It would be a surprisingly quick turnaround for Bowers, especially after he dealt with knee issues throughout the 2025 season. As long as it doesn’t affect his play, fantasy managers will be thrilled to get their superstar tight end back after just one week. In the meantime, Michael Mayer will start in his place. Mayer profiles as a mid-range TE2 for Week 1 versus the Dolphins.
According to Schefter, the Giants still haven’t gotten clarity from Nabers, who is working his way back from the torn ACL he suffered early in the 2025 season. The Giants elevated two receivers from their practice squad to the active roster over the weekend, signaling that they think there’s a chance Nabers sits. If he does, Malachi Fields, Odell Beckham, and Darnell Mooney would be their starting receiver trio. We can’t recommend any of them in fantasy, even if Nabers is ruled out.
According to Pelissero, Garrett had been dealing with lower leg pain and “wasn’t himself” in Week 1 against the 49ers. Garrett was routinely taken off the field and failed to record a single stat in the contest. Per Pelissero, the team hopes he will miss only a minimum of four weeks while on injured reserve. The impending return of Aaron Donald should help ease the loss of Garrett, but this is undoubtedly a massive blow to the Rams’ defense.
Jordan is a healthy scratch after missing most of the last two seasons to injury. No real surprises here. Thomas was just acquired in trade at last cuts and will likely play his way into a reserve role at some point. The only player who was out or questionable for the Texans on the Friday injury report was Kayden McDonald, who headed to injured reserve.
He came on to the practice field for the first time since suffering the injury in training camp on Friday, but it was too little, too late. Ray Davis will likely pick up extra snaps and James Cook will be more involved in the passing game in Week 1 in a tough matchup. Also inactive for the Bills are: WR Skyler Bell, OT Jude Bowry, G Ar’maj Reed-Adams, DL T.J. Sanders, OLB Mike Danna and S Jalon Kilgore.
Izien was dealing with a groin issue this week and received a questionable designation on Friday. The Lions are otherwise a fairly healthy team headed into Week 1.
As is Sean Tucker (hamstring). McMillan’s immediate absence will force the Bucs to dig in to their young receiving depth earlier than they would have liked, but rookie Ted Hurst is not a bad fall-back option for the club. For fantasy managers, however, Hurst is not yet an option even in 14-team leagues. Also inactive for the Bucs are OT Justin Skule, CB Ayden Garnes, DL DeMonte Capehart, DL Elijah Simmons and OG Billy Schrauth.
Odunze missed some practice time this week with the calf issue and was considered questionable headed into the weekend. He could see his snaps and routes limited if the calf is still bothering him. Odunze should be considered a high-variance flex option with a frightening floor against the Panthers. Bears declared QB Tyson Bagent, QB Miller Moss, S Xavier Woods, OT Ozzy Trapilo, DE Jamree Kromah, and OL Jordan McFadden inactive for the team’s season opener.
Kamara practiced in full this week, but the Saints are going to give him at least seven more days to get fully healthy. Kendre Miller will back up Travis Etienne. Also inactive for the Saints are TE Oscar Delp, QB Zach Wilson, OL Mason Murphy, EDGE Cameron Jordan, DL John Ridgeway III, and DL Khristian Boyd.
Jenkins missed the last two practices of Week 1 with a back injury that flared up. He is the starting right guard for the Browns’ offensive line but will now miss this week against the Jaguars. The other injury inactive is backup center Parker Brailsford (thumb), who got in some limited practices but is not healthy enough to be active just yet. Rookie Taylen Green will serve as the team’s emergency third quarterback.
Tucker’s expected absence is a nice little boost for Bucky Irving as he looks to shore up his RB2 value following a disastrous 2025. Kenneth Gainwell is unlikely to battle Iriving for goal-line handles. Seeing as Tucker received a “doubtful” tag for Week 1, he’s likely on the wrong side of questionable for Week 2, but his return will at least be a possibility.
Walker (groin) entered the weekend with a questionable tag, but will be held out of the season opener, while both Madubuike and Buchanan were ruled out on Friday. The Ravens enter Week 1 at near full strength as they prepare to usher in the Jesse Minter era in Baltimore after being led by former head coach John Harbaugh the previous 19 seasons.
Ponds had a doubtful status despite three limited practices this week and looks to be questionable for Week 2, when he’ll again try to make his NFL Debut. Also inactive for the Jets are: KR Kene Nwangwu (back), K Blake Grupe, LB Trevin Wallace and ED Joseph Ossai (foot.) Ossai is regarded as week-to-week and Nwangwu’s back was a surprise Friday listing on the injury report.
He was ruled out on Friday and the only person who made it to Tennessee’s final injury report of the week. The healthy scratches here are RB Nick Singleton, LB Owen Pappoe, CB Jaylon Jones, G Atonio Mafi, T Brandon Crenshaw-Dickson and DT Jackie Marshall.
Sanders, who worked through a lingering ankle injury this offseason, won’t suit up for the team’s season opener. That leaves Darren Waller and Tommy Tremble as the Panthers’ top two tight ends against Chicago. Waller will be a touchdown-dependent TE2 option who probably won’t run many routes in the run-first Carolina offense. Tremble should remain on waiver wires.
There’s nothing too surprising here. Ajiake was the only player carrying an injury designation heading into the weekend, but after popping up as a DNP on Friday, it was assumed he would be sidelined for the season opener. The Colts are set to play host to the Ravens in what will be Daniel Jones’ first game back since he suffered a torn Achilles in Week 14 last season.
The Bengals would obviously prefer Stewart to be out there vs. the Bucs, but it’s an otherwise quiet list for the opener.