Harris will probably have a real chance to play in Week 8, after the Chargers’ Week 7 bye. He thudded to a 16-yard outing in his big chance last week with Quentin Johnston and Ladd McConkey out and doesn’t necessarily need to be rostered if you’re in a bye week crunch.
Last week’s offensive line in front of Justin Herbert featured four rookies and Cole Strange. It doesn’t look like it’s getting much better in Week 6.
A report in September told us that Etienne would be ready to come off injured reserve ahead of Week 6’s game against the Eagles. That appears to be coming to fruition. He’ll try to cut into AJ Dillon’s reserve role.
Schefter reached out to the team after a league source told him the Chargers could get upwards of three first-round draft picks in exchange for Herbert. The Chargers source told Schefter the team has “never” discussed the idea of dealing Herbert, even as the Chargers start the season 0-5 and rank near the bottom in almost every offensive category. It would seem unlikely that the Chargers would consider trading Herbert even if they go all in on a rebuild following the 2026 season. Herbert, 28, who ranks 33rd out of 34 qualifying quarterbacks in EPA per drop back this year, is signed through the 2029 season.
With Deebo Samuel sustaining a serious hamstring injury in Week 5 against Seattle, Cooks stepped in and functioned as San Francisco’s No. 2 receiver behind Mike Evans. Cooks was targeted on 17 percent of his pass routes against the Seahawks and caught a touchdown on his only reception. Though Jacob Cowing could mix in with Samuel sidelined, Cooks should be in line for a few targets a game. The well-traveled veteran can be picked up in deeper fantasy formats this week.
Hudson tore his pec in Week 5’s win over the Dolphins. The injury will likely keep him sidelined for the remainder of the regular season. Hudson had played 28 percent of the team’s offensive snaps and seen seven targets through five games, mostly functioning as a blocker. Drew Sample would see more snaps with Hudson sidelined.
Henderson suffered his latest ankle injury in Week 5 against the Raiders. Schefter said Henderson is “regarded as a quick healer, so the Patriots are hoping his return is sooner rather than later.” Still, he could be sidelined for the next few weeks, leaving Rhamondre Stevenson as the team’s clear lead back. Corey Kiner, meanwhile, appears to be in line as the Patriots’ RB2 after seeing seven touches last week against the Raiders. Kiner should be stashed in most 12-team fantasy leagues for now. Stevenson profiles as a top-12 play until Henderson returns.
Harrison, who sustained the injury in Week 5 against the Eagles, could miss the rest of the season once doctors determine the severity of his knee injury, according to NFL Network’s Ian Rapoport. Harrison had protected Trevor Lawrence’s blindside before the injury. His absence could be a problem for a Jacksonville offensive line that has the league’s third worst pass blocking win rate.
Cook’s elite rushing line was overshadowed by two fumbles, the second of which was a lost fumble on the team’s first possession of overtime, placing the Rams in position to complete the comeback and steal away the victory. A blocked field goal on what would have been the game-winning kick breathed new life into the Bills, who demonstrated confidence in their lead back by throwing him right back out there on the following possession to eventually win the game. The 26 touches go down as a season high for the veteran back, who found paint for the fourth consecutive game in the thrilling overtime win. Cook remains a top-tier RB1 for fantasy purposes ahead of a Week 6 meeting with the Raiders in Las Vegas.
Shakir’s modest target total was primarily a product of a ground-heavy approach from the Bills, who were playing without both DJ Moore and Joshua Palmer. His quiet fantasy outing was quickly remedied through a 57-yard, catch-and-run reception on the team’s second possession of overtime to set up the game-winning, Tyler Bass field goal. Shakir remains a shaky fantasy bet ahead of a Week 6 meeting with the Raiders.
Coleman was largely erased by the lockdown corner play of the Rams but had a receiving line also heavily influenced by a ground-heavy game plan from a Bills team that attempted only 19 passes in almost 70 minutes of football. It was quite the letdown fantasy performance for managers looking to take advantage of the absences of both DJ Moore and Joshua Palmer. Coleman is a borderline FLEX play in Week 6 against the Raiders, pending the status of Moore.
The Bills clearly came into this one intent on establishing the run, attempting 37 rushes to just 19 Josh Allen pass attempts in a game played without both DJ Moore and Joshua Palmer. Kincaid has now seen three or fewer targets in each of his last three games after erupting for 225 yards through the air in the first two weeks. The ceiling was never in question, but fantasy managers have to be reeling after three consecutive down performances for the enigmatic tight end. Kincaid remains an upside TE1 ahead of a Week 6 meeting with the Raiders.
It was the third consecutive game in which Stafford attempted 51 passes or more in what has become the most voluminous passing offense in the league. The two powerhouses felt each other out throughout the first half as only 20 combined points per scored before the break. Things would get aggressive for the final 30 minutes as seven combined touchdowns were scored on nine second half possessions, four of which were accounted for by the Rams. Stafford directed a whopping 24 targets toward alpha wide receiver Puka Nacua, who set a career high with 17 receptions in a short-area role. The reigning MVP returned an instant classic performance against the 2024 MVP, ultimately coming up short in overtime following a blocked field goal attempt from Harrison Mevis. The Rams fall to 2-3 ahead of a home matchup against the more forgiving Cardinals in Week 6. Stafford is once again a fantasy QB1 in that matchup.
Williams has yet to see more than the 16 carries he saw against the Bills this season but the team’s recent pass-heavy nature has left the veteran lead back with six or more receptions in three straight games, including 27 total targets in that span. The elite-level aerial volume made it three consecutive games with 20 or more opportunities for Williams, who continues to return RB1 fantasy weeks while playing in one of the league’s top offenses. Williams remains a middling RB1 ahead of a Week 6 divisional showdown against the Cardinals at home.
Corum provided a much needed spark in relief of lead back Kyren Williams, contributing three clutch receptions that kept drives alive in addition to a third quarter touchdown. That said, his modest volume continued while Williams turned in a third straight game with 20 or more opportunities, including 28 total targets in that stretch. Corum remains a top fantasy handcuff but is unlikely to return useful fantasy weeks for as long as Williams is healthy.
Nacua operated as the primary option through the air for a Rams team that attempted more than 50 passes for the third straight game. The veteran alpha was mostly confined to short-area work, something that could be attributed to the groin injury that continues to have his name on the injury report in practice, but that would not keep Nacua from returning another elite WR1 performance. Nacua was also inches away from padding his stat line further after failing to come down with what would have been a 51-yard touchdown reception on the final play of the first half. Nacua and the Rams fall to 2-3 ahead of a Week 6 divisional showdown against the Cardinals, where he will remain one of the top fantasy assets in the league.
Higbee continued to operate as the primary pass-catching tight end against the Bills, something that must please fantasy managers considering Colby Parkinson returned from a one-game absence. Furthermore, the team carried only three tight ends on the active game-day roster after being at either four or five through the first month of the 2026 season. Higbee is a middling TE2 in fantasy circles ahead of a juicy matchup against the divisional rival Cardinals in Week 6.
Adams cashed in on a corner fade from four yards out in the second quarter and ran a beautiful route on a double move slant from five yards out for his second score in the fourth quarter, proving that he remains an elite red zone weapon for an offense that has now attempted 51 or more passes in three straight games. Adams is back to modest target rates following the Week 4 return of Puka Nacua but remains a weekly WR2 due to his red zone acumen, which remains true ahead of a much more forgiving matchup against the Cardinals in Week 6.
The two teams mustered only 20 combined points in the first half as they felt each other out. There were only two punts after the break between the two sides, who combined for seven touchdowns on nine combined possessions including five straight touchdowns in the fourth quarter to send the game to overtime. Allen and the Bills took the ball first in the extra frame and quickly found themselves deep in enemy territory following a 57-yard, catch-and-run pass to Khalil Shakir. A James Cook fumble on the next play appeared to shatter Allen’s chances of earning his first career win in overtime, but a blocked 48-yard field goal attempt from Harrison Mevis gave the ball back to the Bills with a chance to win. Two Josh Allen scrambles set up a game-winning, 45-yard field goal for Tyler Bass. Allen ended with the second most yards on the ground of his career as the Bills moved to 4-1 with the wild win. Allen remains the top overall quarterback in fantasy circles ahead of a Week 6 meeting with the Raiders on the road.
Estime’s signing comes as Quinshon Judkins is dealing with an ankle injury he suffered in Week 5. Estime, who is only 23 years old, already feels like an NFL journeyman as he now heads to his fifth team in three seasons after brief stints with the Broncos, Eagles, Saints, and Vikings. The former fifth-round pick has rushed for 508 yards and three touchdowns in his career and rushed for 76-310-2 as a rookie with the Broncos. Estime could see snaps in Week 6 against the Ravens if Judkins is unable to play, but we wouldn’t expect to see anything close to a meaningful workload at this time.
Moore’s absence leaves only Keon Coleman, Khalil Shakir, Greg Dortch, and Skyler Bell as healthy wide receivers on the active roster with Joshua Palmer also sidelined. Expect heavy snap rates for Coleman and Shakir alongside tight end Dalton Kincaid, with the possibility the team elevates their 12-personnel rates through the inclusion of Dawson Knox. Also inactive for the Bills are WR Joshua Palmer, OL Jude Bowry, OL Ar’maj Reed-Adams, DL Ed Oliver DL, Landon Jackson, and NCB Dee Alford.
Smith-Schuster was released by the Giants in training camp, and last worked out for the Jets in September. The 29-year-old receiver caught 33 passes for 345 yards and one touchdown last season, but wouldn’t be anything more than a depth signing if he were to sign with the Vikings or another team this season.
Cooper, who is facing felony assault charges and domestic violence and harassment charges, appeared in court on Monday and is currently on the commissioner’s exempt list. With his pretrial set for February 19th and his new trial date set for March 2nd, it’s possible Cooper could be removed from the exempt list now that his trial is set for after the season. Cooper has not played a game for the Broncos this season.
No real surprise after Mendoza’s mop-up appearance in Week 5. It doesn’t appear that he’s taken a major step towards unseating Cousins — who has played well — just yet. But it remains a reasonable bet to happen in the near future.